Three decades ago, only a small number of researchers talked about gut hormones. Today, many people view these hormones as building blocks for developing new therapies to confront the obesity and diabetes epidemics that are sweeping the world. Daniel J. Drucker has studied the molecular mechanisms and physiological functions of hormones for 35 years. His studies unravelling their biological actions have led to several discoveries and the development of life-changing therapies. For his outstanding contributions, he is receiving the 2019 EASD–Novo Nordisk Foundation Diabetes Prize for Excellence.